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Younghwa Na Selected Research

pyridine

5/2016A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.
1/2016Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
10/2015Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents.
3/2010Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
1/20102-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
1/20102,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.

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Younghwa Na Research Topics

Disease

32Neoplasms (Cancer)
04/2021 - 07/2003
5Breast Neoplasms (Breast Cancer)
04/2021 - 10/2013
4Lung Neoplasms (Lung Cancer)
04/2021 - 08/2016
2Neoplasm Metastasis (Metastasis)
04/2021 - 01/2019
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2021 - 12/2017
2Body Weight (Weight, Body)
04/2021 - 04/2016
2Fibrosis (Cirrhosis)
08/2020 - 01/2019
2Prostatic Neoplasms (Prostate Cancer)
07/2016 - 01/2011
2Inflammation (Inflammations)
07/2016 - 04/2016
2Obesity
04/2016 - 07/2012
1Pathologic Neovascularization
10/2018
1Blindness (Hysterical Blindness)
10/2018
1Pneumonia (Pneumonitis)
01/2018
1Radiation Pneumonitis
01/2018
1Primary Ovarian Insufficiency
10/2017
1Neuroblastoma
10/2016
1Liver Neoplasms (Liver Cancer)
09/2014
1Colorectal Neoplasms (Colorectal Cancer)
11/2013
1Stomach Neoplasms (Stomach Cancer)
12/2012
1Alzheimer Disease (Alzheimer's Disease)
11/2011
1Type 2 Diabetes Mellitus (MODY)
06/2011

Drug/Important Bio-Agent (IBA)

12Type I DNA Topoisomerases (Topoisomerase I)IBA
11/2016 - 07/2007
6Antineoplastic Agents (Antineoplastics)IBA
10/2017 - 01/2010
6pyridineIBA
05/2016 - 01/2010
4Etoposide (VP 16)FDA LinkGeneric
11/2016 - 11/2013
4PyridinesIBA
01/2016 - 05/2010
4Type II DNA Topoisomerases (Topoisomerase II)IBA
10/2015 - 07/2003
4DNA (Deoxyribonucleic Acid)IBA
02/2015 - 07/2003
3HSP27 Heat-Shock ProteinsIBA
04/2021 - 08/2016
3Cisplatin (Platino)FDA LinkGeneric
04/2021 - 10/2017
3Proteins (Proteins, Gene)FDA Link
04/2021 - 10/2013
3Biological ProductsIBA
01/2019 - 12/2009
2Pharmaceutical PreparationsIBA
04/2021 - 06/2009
2CytokinesIBA
01/2019 - 07/2016
2EnzymesIBA
10/2016 - 06/2011
2xanthoneIBA
08/2016 - 06/2009
2trioctyl phosphine oxide (TOPO)IBA
01/2016 - 07/2015
2Doxorubicin (Adriamycin)FDA LinkGeneric
10/2015 - 09/2010
2Hydroxyl RadicalIBA
07/2015 - 05/2010
1zerumboneIBA
04/2021
1Gefitinib (Iressa)FDA Link
04/2021
19 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA
04/2021
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
04/2021
1Bleomycin (Blenoxane)FDA LinkGeneric
08/2020
1Acetyl Coenzyme A (Acetyl-CoA)IBA
08/2020
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
06/2020
1Trastuzumab (Herceptin)FDA Link
06/2020
1human ERBB2 proteinIBA
06/2020
1Interleukin-6 (Interleukin 6)IBA
01/2019
1Transforming Growth Factors (Transforming Growth Factor)IBA
01/2019
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2018
1HSP27 inhibitor J2IBA
01/2018
1Amifostine (Ethyol)FDA LinkGeneric
01/2018
1QuinolonesIBA
12/2017
1ChromonesIBA
10/2017
1MelatoninIBA
10/2017
1GhrelinIBA
10/2017
1Neuroprotective AgentsIBA
10/2016
1Apoptosis Regulatory ProteinsIBA
08/2016
1TransducinIBA
07/2016
1AndrogensIBA
07/2016
1Glucose (Dextrose)FDA LinkGeneric
04/2016
1p38 Mitogen-Activated Protein KinasesIBA
04/2016
1licochalcone FIBA
04/2016
1LuciferasesIBA
04/2016
1Topoisomerase II InhibitorsIBA
10/2015
1LigandsIBA
09/2014
1Protein Kinases (Protein Kinase)IBA
09/2014
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2014
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
09/2014
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
09/2014
1N-dodecyl-L-lysine amideIBA
09/2014
1Casein Kinase II (Casein Kinase 2)IBA
09/2014
1dithiiranylmethyloxy azaxanthoneIBA
10/2013
1TamoxifenFDA LinkGeneric
10/2013
1Cathepsin BIBA
06/2013
1ChalconesIBA
06/2013
1A 62176IBA
12/2012
1Cyclin D1IBA
12/2012
1quinolineIBA
02/2012
1Amyloid (Amyloid Fibrils)IBA
11/2011
1Peptides (Polypeptides)IBA
11/2011
1GlucosidasesIBA
06/2011
1procyanidin B3IBA
01/2011
1Androgen Receptors (Androgen Receptor)IBA
01/2011
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
01/2011
1XanthonesIBA
09/2010
1AcridonesIBA
12/2009
1PoisonsIBA
07/2003
1Alkylating AgentsIBA
07/2003

Therapy/Procedure

6Therapeutics
04/2021 - 08/2016
4Drug Therapy (Chemotherapy)
04/2021 - 10/2017
2Radiotherapy
01/2019 - 01/2018